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How should you take this medication? If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose , skip the missed dose and continue your regular dosing schedule.

If you take Zyban once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not t ake a double dose to make up for a missed one.

Side Effects of This Medicine Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
- Agitation; anxiety

Less common
- Buzzing or ringing in ears; headache (severe); sk in rash, hives, or itching

Rare
- Confusion; extreme distrust; fainting; false beliefs that cannot be changed by facts; hallucinations (seeing, hearing, or feeling things that are not there); seizures (convulsions), especially with higher doses; trouble in concentrating

Management of Overdoses: Fast heartbeat; hallucinations (seeing, hearing, or feeling things that are not there); loss of consciousness ; nausea; seizures (convulsions) ; vomiting

Before Taking This Medicine Allergies¡XTell your doctor if you have ever had any unusual or allergic reaction to Zyban. Also tell your health care professional if you are allergic to any other substances, such as foods, preserva ives, or dyes.

What is this Drug Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10

Possible food and drug interactions when taking this medication When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:

- Alcohol or
- Antipsychotics (medicine for mental illness) or
- Corticosteriods(cortisone-like medicine) or
- Fluoxetine (e.g., Prozac) or
- Lithium (e.g., Lithane) or
- Maprotiline (e.g., Ludiomil) or
- Theophylline (e.g., S omophyllin-T) or
- Trazodone (e.g., Desyrel) or
- Ritonavir (e.g., Norvir)¡XUsing these medicines with Zyban may increase the risk of seizures


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